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Dexamethasone tablet strengths of 0.625mg/24mg and 1mg/24mg. Patients will be asked to provide a reason for treatment adherence, as their will be re-evaluated every 6-12 weeks. The primary outcome is change in the mean total T-3 and T-12 of 2-5 weeks' duration. Secondary outcomes include the mean change in T-3, T-12 or mean age at the end of week 3, and changes in serum concentrations of the biomarkers prostate cancer treatment. Treatment guidelines from the American Society of Clinical Oncology recommend the use of tamoxifen, raloxifene, raloxifene/bayer, and raloxifene/dexamethasone tablet strengths of 0.25mg/48mg; 0.625mg/24mg; 0.625mg/48mg; 1mg/24mg; and 1mg/48mg. Patients where to buy dexamethasone injection will be asked to provide a reason for treatment adherence, as their will be re-evaluated every 6-12 weeks. The primary outcome is change in the mean total T-3 and T-12 of 2-5 weeks' duration. Secondary outcomes include the mean change in T-3, T-12 or mean age at the end of week 3, and changes in serum concentrations of the biomarkers prostate cancer treatment. Interventional data review The protocol for study (PROSPERO-0118) was approved by the ethics committee of University Buenos Aires, the Argentine Medical Ethics Review Committee and the of University Southern California. After an informed consent form giving to participate in the study was collected prior to completing the online questionnaire (as described below), all patients provided a fasting serum sample, and urine sample was collected. Participants were enrolled from August 2007 to November 2008 and assigned randomly to tamoxifen, raloxifene, raloxifene/dexamethasone, and 1mg/24mg treatment groups. All participants had a complete medical history (except non-melanoma skin cancer) and complete metabolic assessment, had no significant medical exclusion. In addition, no treatment with a hormonal therapy within the preceding 8 weeks was allowed (for example, gonadotrophins or antineoplastic chemotherapy). The protocol for each group was approved by the ethics committee of University Buenos Aires, the Argentine Medical Ethics Review Committee and the of University Southern California. Baseline analysis To examine differences in progression-free survival and serum biomarker analysis outcome, the Kaplan-Meier survival analyses were performed according to treatment assignment. Progestin and non-hormone groups in our previous study [15] were not different, and therefore we performed the same analyses for these two outcomes. In the same vein, results of age at diagnosis (Table 2) and the incidence health canada online drug query (Figure 3, Panel B) were analyzed according to treatment assignment using both stratified and unstratified proportional hazards models. We performed stratified analyses with follow-up time. The Kaplan-Meier analyses indicated no significant difference in treatment assignment. Figure 3 Open in a separate window Assessment of the outcome metrics At baseline visit, all patients were also assessed for PSA levels (Table 3). Prostate-specific antigen (PSA) levels were calculated from patients' baseline measurements the beginning (week 0) to end of the trial, calculated from average of baseline measurements weeks 0.
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